RecruitingNCT04678011

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

1,000 participants

Start Date

Nov 24, 2021

Study Type

OBSERVATIONAL

Conditions

Familial Adenomatous Polyposis

Summary

The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
Age 18 years or older

Exclusion Criteria3

Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
Cancer at baseline endoscopy
Need for surgery

Interventions

PROCEDUREPersonalized surveillance and intervention protocol

This study uses one arm. Participants will undergo endoscopic surveillance with intervals between 6 months and 2 years, depending on severity of polyposis and performed endoscopic interventions.

Locations(2)

MD Anderson

Houston, Texas, United States

Academic Medical Centre

Amsterdam, North Holland, Netherlands

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04678011

Related Trials

Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

NCT056307945 locations

A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

NCT046779982 locations