Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain
University of Washington
90 participants
May 1, 2021
INTERVENTIONAL
Conditions
Summary
High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called arterial spin labeling (ASL) on an MRI and is tightly related to brain metabolism.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
100 ml of dairy cream with 40.4g of total fat, to ingest orally
Locations(1)
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NCT04692441