RecruitingNot ApplicableNCT04692441

Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain


Sponsor

University of Washington

Enrollment

90 participants

Start Date

May 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called arterial spin labeling (ASL) on an MRI and is tightly related to brain metabolism.


Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This research study explores how a gene variant called APOE E4 — a known risk factor for Alzheimer's disease — affects blood fat (triglyceride) levels and blood flow in the brain. Researchers hope this will help understand why APOE E4 raises dementia risk. **You may be eligible if...** - You are 55 years old or older - You are able to undergo an MRI scan - You are able to consume dairy products - You can read, understand, and communicate in English - You are post-menopausal (if a woman) **You may NOT be eligible if...** - You have diabetes requiring medication (insulin or oral medication) - You take medication for high blood pressure - You have certain heart conditions or take specific medications that could interfere with results - You have claustrophobia or a metal implant preventing MRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTHeavy Cream

100 ml of dairy cream with 40.4g of total fat, to ingest orally


Locations(1)

University of Washington Medical Center

Seattle, Washington, United States

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NCT04692441


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