Dementia Clinical Trials

457 recruitingLast updated: June 17, 2026

There are 457 actively recruiting dementia clinical trials across 45 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Boston, Massachusetts, United States, Toronto, Ontario, Canada, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Dementia Trials at a Glance

457 actively recruiting trials for dementia are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Not Applicable with 188 trials, with the heaviest enrollment activity in Boston, Toronto, and New York. Lead sponsors running dementia studies include Massachusetts General Hospital, Duke University, and The University of Hong Kong.

Treatments under study

About Dementia Clinical Trials

Looking for clinical trials for Dementia? There are currently 397 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Dementia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Dementia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 457 trials

Recruiting
Not Applicable

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

DementiaMild Cognitive Impairment (MCI)Potentially Inappropriate Medication Use
Johns Hopkins University100 enrolled1 locationNCT07454824
Recruiting

Genetic Characterization of Movement Disorders and Dementias

DementiaMovement Disorder
National Institute on Aging (NIA)12,000 enrolled1 locationNCT02014246
Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral SclerosisFrontotemporal DementiaProgressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke (NINDS)360 enrolled1 locationNCT03225144
Recruiting
Phase 2

Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

Older Adults With Elevated Dementia Risk
University of South Carolina54 enrolled1 locationNCT07638046
Recruiting

Clinical Procedures to Support Research in ALS

Amyotrophic Lateral SclerosisPrimary Lateral SclerosisProgressive Muscular Atrophy+1 more
University of Miami1,200 enrolled11 locationsNCT03489278
Recruiting
Not Applicable

Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

DementiaInsomnia Chronic
University of South Florida60 enrolled1 locationNCT04632628
Recruiting
Phase 1Phase 2

Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease

Alzheimer Dementia (AD)
The Methodist Hospital Research Institute30 enrolled1 locationNCT07651319
Recruiting
Not Applicable

Music for Pain and Dementia

DementiaCaregiverAlzheimer Disease+2 more
Yale University60 enrolled1 locationNCT07602283
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting

Natural History Study of Synucleinopathies

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+5 more
NYU Langone Health800 enrolled8 locationsNCT01799915
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
Stephanie Grasso60 enrolled3 locationsNCT05741853
Recruiting
Early Phase 1

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled2 locationsNCT07213700
Recruiting
Phase 2Phase 3

Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia

Agitation Associated With Alzheimer's Disease Dementia
Exciva GmbH300 enrolled49 locationsNCT07284472
Recruiting
Not Applicable

SUNAM Protocol for Managing BPSD

Dementia
Mackay Medical College120 enrolled2 locationsNCT07041034
Recruiting

Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Mild Cognitive Impairment (MCI)Other DementiasCognitively Unimpaired+1 more
Karolinska Institutet600 enrolled1 locationNCT07629349
Recruiting
Not Applicable

BCI With 40Hz Stimulation in Alzheimer's Disease

Alzheimer Dementia (AD)
Ruijin Hospital90 enrolled2 locationsNCT07618481
Recruiting
Not Applicable

Resilient Together for Dementia (RT-D)

Dementia
Icahn School of Medicine at Mount Sinai24 enrolled1 locationNCT06619327
Recruiting
Phase 4

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Cardiovascular DiseasesDementiaCognitive Impairment, Mild
Duke University20,000 enrolled103 locationsNCT04262206