Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

This study (called CROME) combines two treatments — cryoablation (freezing the tumor) and stereotactic body radiation (precisely targeted radiation) — to treat painful bone metastases in cancers that often respond poorly to radiation alone, such as kidney cancer, prostate cancer, melanoma, and others. **You may be eligible if...** - You have a confirmed cancer diagnosis with bone metastases visible on imaging - Your cancer is one of the eligible types: renal cell carcinoma, urothelial cancer, castration-resistant prostate cancer, sarcoma, thyroid cancer, colorectal cancer, or melanoma - Your target bone lesion is 7 cm or smaller - Your pain from the bone lesion is at least 4 out of 10 on a pain scale - The lesion is suitable for both cryoablation and radiation (as determined by the study team) **You may NOT be eligible if...** - Your lesion is larger than 7 cm or cannot safely undergo both procedures - Your pain level is below 4 out of 10 - Your cancer type is not on the eligible list Talk to your doctor to see if this trial is right for you.