Metastatic Prostate Carcinoma Clinical Trials

15 recruiting

Metastatic Prostate Carcinoma Trials at a Glance

21 actively recruiting trials for metastatic prostate carcinoma are listed on ClinicalTrialsFinder across 6 cities in 4 countries. The largest study group is Phase 2 with 6 trials, with the heaviest enrollment activity in Los Angeles, Philadelphia, and Eau Claire. Lead sponsors running metastatic prostate carcinoma studies include Mayo Clinic, City of Hope Medical Center, and National Cancer Institute (NCI).

Browse metastatic prostate carcinoma trials by phase

Treatments under study

About Metastatic Prostate Carcinoma Clinical Trials

Looking for clinical trials for Metastatic Prostate Carcinoma? There are currently 15 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metastatic Prostate Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metastatic Prostate Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Phase 1

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8
Roswell Park Cancer Institute14 enrolled1 locationNCT06305598
Recruiting
Not Applicable

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Metastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell Carcinoma+15 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT04693377
Recruiting
Not Applicable

Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

Metastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8
Thomas Jefferson University120 enrolled1 locationNCT05487846
Recruiting
Phase 2

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast Carcinoma+28 more
National Cancer Institute (NCI)36 enrolled4 locationsNCT04550494
Recruiting
Not Applicable

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

Stage III Prostate Cancer AJCC v8Localized Prostate CarcinomaStage I Prostate Cancer AJCC v8+3 more
Mayo Clinic50 enrolled1 locationNCT06389786
Recruiting

National Cancer Institute "Cancer Moonshot Biobank"

Ovarian CarcinomaEsophageal CarcinomaGastric Carcinoma+26 more
National Cancer Institute (NCI)1,600 enrolled152 locationsNCT04314401
Recruiting
Phase 3

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Metastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8Biochemically Recurrent Prostate Carcinoma+1 more
ECOG-ACRIN Cancer Research Group804 enrolled303 locationsNCT04423211
Recruiting
Phase 2

FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial

Metastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8Castration-Sensitive Prostate Carcinoma
Northwestern University125 enrolled6 locationsNCT06244004
Recruiting
Phase 1

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8+2 more
Jonsson Comprehensive Cancer Center30 enrolled1 locationNCT05398302
Recruiting
Phase 2

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

Locally Advanced Prostate CarcinomaMetastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8+2 more
Mayo Clinic38 enrolled1 locationNCT07073794
Recruiting
Not Applicable

Access to Genetic Testing in Underserved Patients With Cancer

Breast CarcinomaOvarian CarcinomaMalignant Solid Neoplasm+5 more
University of Southern California800 enrolled2 locationsNCT06422455
Recruiting
Early Phase 1

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Localized Prostate Carcinoma+1 more
Mayo Clinic220 enrolled2 locationsNCT05045066
Recruiting

Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8+1 more
University of Washington48 enrolled4 locationsNCT04489719
Recruiting
Phase 3

SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Stage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8Biochemically Recurrent Prostate Carcinoma+4 more
Mayo Clinic118 enrolled6 locationsNCT06205316
Recruiting
Phase 2

Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study

Stage IVB Prostate Cancer AJCC v8Prostate AdenocarcinomaOligometastatic Prostate Carcinoma+2 more
NRG Oncology194 enrolled239 locationsNCT05053152
Recruiting
Not Applicable

Addressing Health Literacy With a Tailored Survivorship Care Plan

Stage IVB Prostate Cancer AJCC v8Localized Prostate CarcinomaOligometastatic Prostate Carcinoma
Emory University150 enrolled3 locationsNCT06674863
Recruiting
Phase 1

PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8
City of Hope Medical Center21 enrolled1 locationNCT05805371
Recruiting
Phase 2

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment of Prostate Cancer

Prostate AdenocarcinomaOligometastatic Prostate Carcinoma
Mayo Clinic110 enrolled1 locationNCT06369610
Recruiting
Phase 2

Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

Prostate CarcinomaMetastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8+2 more
City of Hope Medical Center210 enrolled1 locationNCT05869682
Recruiting

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IIIB Prostate Cancer AJCC v8+1 more
Thomas Jefferson University30 enrolled1 locationNCT05627219