LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

This study is testing a two-step treatment approach for patients with newly diagnosed high-grade gliomas (aggressive brain tumors). The first step uses a minimally invasive laser ablation procedure (LITT), followed by focused radiation therapy (hypofractionated RT) to treat what remains. **You may be eligible if...** - You are 18 or older - Your brain MRI shows a high-grade glioma and you are a candidate for laser ablation (LITT) - You have had an MRI with contrast within the past 60 days - Your general functional status is adequate (Karnofsky ≥50%) - You have adequate blood counts, liver, and kidney function **You may NOT be eligible if...** - You have previously had radiation to the brain - You are pregnant - You cannot safely receive radiation or undergo the laser procedure - Your tumor is not suitable for laser ablation per neurosurgery evaluation Talk to your doctor to see if this trial is right for you.