Brain Tumor Clinical Trials

70 recruiting

Brain Tumor Trials at a Glance

158 actively recruiting trials for brain tumor are listed on ClinicalTrialsFinder across 6 cities in 26 countries. The largest study group is Not Applicable with 50 trials, with the heaviest enrollment activity in Boston, New York, and Houston. Lead sponsors running brain tumor studies include Tata Memorial Centre, InSightec, and Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta.

Browse brain tumor trials by phase

Treatments under study

About Brain Tumor Clinical Trials

Looking for clinical trials for Brain Tumor? There are currently 70 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Brain Tumor trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Brain Tumor clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 158 trials

Recruiting
Phase 1Phase 2

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

CancerBrain Tumor
National Cancer Institute (NCI)96 enrolled1 locationNCT05588141
Recruiting
Phase 2

A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease

Brain Tumor - Metastatic
University of Nebraska100 enrolled2 locationsNCT04222062
Recruiting

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

Brain TumorEpilepsyAutism Spectrum Disorder+3 more
Southwest Autism Research & Resource Center500 enrolled2 locationsNCT04322734
Recruiting
Not Applicable

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

Brain Tumor
St. Jude Children's Research Hospital45 enrolled1 locationNCT05947045
Recruiting
Phase 3

Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue

Cancer-related FatigueBrain Tumor, PediatricMethylphenidate
Odense University Hospital50 enrolled4 locationsNCT06905587
Recruiting
Not Applicable

NK Cell Therapy for Malignant Solid Brain Tumors

Brain MetastasisGlioblastoma Multiforme (GBM)Glioblastoma (GBM)+2 more
Peking University Third Hospital27 enrolled4 locationsNCT07552233
Recruiting
Phase 2

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Metastatic Brain TumorGlioblastomaGlioblastoma Multiforme+7 more
Nationwide Children's Hospital120 enrolled21 locationsNCT05843253
Recruiting
Not Applicable

C-SMART vs BE Well for Patients With Brain Tumors

Brain Tumor
Virginia Commonwealth University42 enrolled1 locationNCT07224503
Recruiting
Not Applicable

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

GlioblastomaBrain Tumor AdultLow Grade Glioma (LGG), High Grade Glioma (HGG)
SonoClear AS15 enrolled4 locationsNCT07042620
Recruiting
Not Applicable

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Brain Tumor
Massachusetts General Hospital100 enrolled1 locationNCT03286335
Recruiting
Not Applicable

Non-invasive Glioma Characterization Through Molecular Imaging

Brain TumorGliomaPrimary Brain Tumor+2 more
University of Miami30 enrolled1 locationNCT03684109
Recruiting
Phase 3

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

Brain Tumor
InSightec30 enrolled10 locationsNCT05317858
Recruiting
Early Phase 1

Study of Letrozole in Recurrent Gliomas

Brain Tumor
University of Cincinnati39 enrolled1 locationNCT03122197
Recruiting
Phase 1

Chronic CED of TPT for Recurrent Malignant Glioma

Brain Tumor, RecurrentMalignant Glioma (WHO Grade III or IV)IDH1/IDH2 Mutation
Jeffrey N. Bruce6 enrolled1 locationNCT06666712
Recruiting
Not Applicable

rTMS for Postoperative Brain Tumor Patients

Quality of LifeBrain TumorsTranscranial Magnetic Stimulation+1 more
Brian J.Gill6 enrolled1 locationNCT07530536
Recruiting
Not Applicable

Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention

Brain Tumor, Pediatric
Institut Claudius Regaud130 enrolled15 locationsNCT06599879
Recruiting
Phase 2

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Brain TumorBrain CancerGlioblastoma+6 more
Northwell Health37 enrolled1 locationNCT02800486
Recruiting
Phase 1Phase 2

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled10 locationsNCT06465199
Recruiting
Phase 1

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Phase 3

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients

NeoplasmsBrain TumorGlioblastoma+5 more
NaviFUS Corporation32 enrolled2 locationsNCT06496971