RecruitingPhase 4NCT04707261

Association Between Dapagliflozin-induced Improvement and Anemia in Heart Failure Patients (ADIDAS)

A Prospective, Randomized, Double-blind, Multicenter Study on the Association Between Dapagliflozin-induced Improvement and Anemia in Heart Failure Patients (ADIDAS)

Sponsor

Xiangtan Central Hospital

Enrollment

1,990 participants

Start Date

Aug 6, 2021

Study Type

INTERVENTIONAL

Conditions

Heart Failure Anemia

Summary

The primary objective of this study is to investigate the hemoglobin change and association between hemoglobin change and readmissions due to heart failure, and all-cause death in patients with heart failure treated with dapagliflozin or placebo.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This trial studies whether dapagliflozin (a diabetes and heart failure drug) can also help improve anemia in people hospitalized with heart failure. **You may be eligible if...** - You are 18–100 years old - You have elevated heart failure markers (NT-proBNP or BNP) on admission - Your heart pumping function (ejection fraction) is 50% or less with NYHA class II, III, or IV symptoms **You may NOT be eligible if...** - You have taken an SGLT2 inhibitor in the past 3 months or had a bad reaction to one - You have severe kidney disease (eGFR below 30) or rapidly worsening kidney disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin

Participants will receive dapagliflozin 10 mg once daily

DRUGPlacebo

Participants will receive placebo 10 mg once daily

Locations(1)

Xiangtan Central Hospital

Xiangtan, Hunan, China

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NCT04707261

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