RecruitingNCT04713722

Early Life Stress and Depression: Molecular and Functional Imaging

Sponsor

Mclean Hospital

Enrollment

160 participants

Start Date

Feb 1, 2021

Study Type

OBSERVATIONAL

Conditions

Depression Trauma, Psychological

Summary

Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 32 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain scans to explore how early life stress is connected to depression. Researchers want to understand the brain chemistry and function behind depression in young women. **You may be eligible if:** - You are a woman between ages 20 and 32 - You are right-handed - You are not currently taking any medications - You speak and read English fluently - You have normal or corrected vision and hearing - No close relatives have a history of psychotic disorders **You may NOT be eligible if:** - You are pregnant or could become pregnant - You have metal implants or other MRI safety concerns - You currently use recreational or illicit drugs - You have a serious medical condition affecting your heart, liver, kidneys, or nervous system - You have a current diagnosis of OCD, ADHD, bipolar disorder, schizophrenia, or an active eating disorder - You have a history of moderate or severe alcohol or substance use disorder within the past year - You have claustrophobia or severe anxiety Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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