Secondhand Tobacco Smoke and Cardiovascular Disease

This study examines how long-term exposure to secondhand tobacco smoke affects the heart and blood vessels — and whether a blood pressure medication can help protect against damage. It focuses on people who were heavily exposed at work before smoking bans were in place. **You may be eligible if:** - You are 40 years of age or older - You have a history of at least 5 years of occupational secondhand smoke exposure (e.g., as a flight attendant before airline smoking bans, or a casino worker before smoke-free policies) - You have never smoked, or you smoked very little (less than 1 pack-year total) and not at all in the past 20 years **You may NOT be eligible if:** - You currently take an ACE inhibitor or ARB blood pressure medication - You have known heart disease, kidney disease, severe lung disease, or significant vascular disease - You are pregnant or breastfeeding - You have very low blood pressure - Your BMI is below 15 or above 40 - You currently use NSAIDs (like ibuprofen) daily Talk to your doctor to see if this trial is right for you.