RecruitingNCT04721418
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Sponsor
Yale University
Enrollment
80 participants
Start Date
Jul 20, 2021
Study Type
OBSERVATIONAL
Conditions
Summary
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
Eligibility
Min Age: 21 YearsMax Age: 60 Years
Inclusion Criteria5
- Age 21-60 years
- Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
- For females, a negative serum pregnancy test
- For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
- For HC: Negative urine toxicology
Exclusion Criteria5
- DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
- A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
- A history of significant and/or uncontrolled medical or neurological illness
- Current use of psychotropic and/or potentially psychoactive prescription medications
- Medical contraindications to MRI procedure
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Interventions
RADIATION11C-UCB-J
11C-UCB-J PET scan
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04721418
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