RecruitingNCT04721418

Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Sponsor

Yale University

Enrollment

80 participants

Start Date

Jul 20, 2021

Study Type

OBSERVATIONAL

Conditions

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Min Age: 21 YearsMax Age: 60 Years

Age 21-60 years
Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
For females, a negative serum pregnancy test
For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
For HC: Negative urine toxicology

DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
A history of significant and/or uncontrolled medical or neurological illness
Current use of psychotropic and/or potentially psychoactive prescription medications
Medical contraindications to MRI procedure

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