RecruitingNCT04725422

CHronic Nonbacterial Osteomyelitis International Registry

CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)

Sponsor

Seattle Children's Hospital

Enrollment

2,000 participants

Start Date

Aug 1, 2018

Study Type

OBSERVATIONAL

Conditions

Chronic Recurrent Multifocal Osteomyelitis Chronic Nonbacterial Osteomyelitis

Summary

The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.

Eligibility

Max Age: 21 Years

Inclusion Criteria4

\- Age at enrollment is equal to or younger than 21 years of age
Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment
Whole body imaging evaluation (either WB MRI or bone scintigraphy)
Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis

Exclusion Criteria3

\- History of or current malignancy
Current infectious osteomyelitis
Contraindication to the selected treatment agent

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