RecruitingNot ApplicableNCT04734847

Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome

Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome: Reducing Pain by Improving Brain and Muscle Activity

Sponsor

University of Southern California

Enrollment

50 participants

Start Date

Jun 1, 2021

Study Type

INTERVENTIONAL

Conditions

Interstitial Cystitis Bladder Pain Syndrome

Summary

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common, chronic, and debilitating condition in women. Preliminary evidence suggests that IC/BPS pain can be reduced applying non-invasive repetitive transcranial magnetic stimulation (rTMS) to areas of the brain that regulate pelvic floor muscle activity. However, prior studies have examined rTMS in a very limited sample and have not examined changes in brain or pelvic floor muscle activity to determine the mechanism of rTMS for IC/BPS. This study is designed to directly address these limitations.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria4

Be at least 18 years old.
Be female.
Have a diagnosis of IC/BPS by the referring physician, with urologic symptoms present a majority of the time during the most recent 3 months
Screen within standard limits for pelvic pain

Exclusion Criteria8

Symptomatic urethral stricture
On-going neurological conditions affecting the bladder or bowel
Active auto-immune or infectious disorders
History of cystitis caused by tuberculosis or radiation or chemotherapies
History of non-dermatologic cancer
Current major psychiatric disorders
Severe cardiac, pulmonary, renal, or hepatic disease
Conditions or the use of medical devices that are contraindications for either fMRI or rTMS procedures, including pregnancy, seizure disorders, or chronic headaches