The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
Massachusetts General Hospital
30 participants
Feb 8, 2022
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.
Eligibility
Inclusion Criteria3
- Adult male or non-pregnant female volunteers (age 18+)
- Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for >48 hours
- Able and willing to give consent and comply with study procedures
Exclusion Criteria8
- Blind, deaf or unable to speak English
- Women who are pregnant or nursing
- Contraindications to safe use enteral nutrition, including gastrointestinal obstruction
- Personal history of intestinal malabsorption, gallbladder disease or pancreatitis
- Dietary restrictions precluding enteral feeds
- Renal and liver failure requiring dialysis or Child-Pugh score > 7
- Severe deficit due to structural or anoxic brain damage
- With skin condition that precludes wearing sensors
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Interventions
Enteral nutrition (tube feeds) will be provided during the daytime followed by nighttime.
Enteral nutrition (tube feeds) will be provided during the nighttime followed by daytime.
Locations(1)
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NCT04737200