Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

This study tests whether metformin — a common diabetes drug — can prevent low-risk bone marrow conditions (called CCUS and low-risk MDS) from progressing into more serious blood cancers like leukemia. **You may be eligible if...** - You have been diagnosed with low-risk MDS (very low or low risk by the IPSS-R scoring system) OR a condition called CCUS (persistent low blood counts with genetic changes, but not yet diagnosed as MDS or leukemia) - Your bone marrow blast percentage is under 5% - You have had persistent low blood counts for at least 6 months - You are in generally adequate health **You may NOT be eligible if...** - Your MDS is classified as intermediate, high, or very high risk - You are already taking metformin for diabetes or another reason - You have significant kidney problems (metformin is not safe with poor kidney function) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.