RecruitingNCT04763317

Precision Medicine in the Prostate Cancer Care Pathway

Precision Medicine in the Prostate Cancer Care Pathway: an Evaluation of Integrating Germline Genetic Testing Into the Management of Men at Risk of / Living With Prostate Cancer

Sponsor

Institute of Cancer Research, United Kingdom

Enrollment

3,000 participants

Start Date

Feb 14, 2019

Study Type

OBSERVATIONAL

Conditions

Prostate Cancer Genetic Predisposition

Summary

This study aims to evaluate the use of a prostate cancer specific predisposition genetic panel test in men with / at high risk of prostate cancer. The genetic test will analyse men's DNA samples for the presence of mutations in rare genes as well as common genetic variation to provide men with information about their risk of prostate cancer. This study will evaluate the clinical impact of the test on risk assessment and clinical management in terms of screening and treatment.

Eligibility

Sex: MALEMin Age: 30 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring genetic testing and precision medicine approaches for prostate cancer patients and their at-risk family members, focusing on men diagnosed at a young age or with aggressive or metastatic disease. **You may be eligible if...** - You have been diagnosed with prostate cancer before age 60, OR - You have metastatic castration-resistant prostate cancer at any age, OR - You have aggressive prostate cancer (Gleason 4+4 or higher) diagnosed before age 70, OR - You have three or more first- or second-degree relatives with prostate cancer **You may NOT be eligible if...** - You do not meet any of the above prostate cancer criteria - You are below the minimum age thresholds for each category Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

GENETICProstate cancer risk gene panel

A list of genes created by study experts, thought to increase the risk of prostate cancer from from review previous research, this list is regularly reviewed for accuracy