RecruitingNot ApplicableNCT04763655

Neural Biomarkers of Electroconvulsive Therapy Response

Neural Biomarkers of Electroconvulsive Therapy Response in Schizophrenia

Sponsor

Northwell Health

Enrollment

75 participants

Start Date

Apr 1, 2020

Study Type

INTERVENTIONAL

Conditions

Electroconvulsive Therapy Treated Patients

Summary

In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal where patients will be followed up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is using brain imaging (EEG and other tests) before and during electroconvulsive therapy (ECT — a treatment involving brief electrical stimulation of the brain under anesthesia) to identify biological markers that predict who will respond to this treatment for serious psychiatric conditions. **You may be eligible if...** - You are experiencing moderate to severe psychotic symptoms (hallucinations, unusual thoughts, or disorganized thinking) - You have not responded to at least one antipsychotic medication trial of 6 weeks - You are competent and willing to give informed consent - You have a negative pregnancy test (for women) and agree to use contraception **You may NOT be eligible if...** - You have not tried at least one antipsychotic medication - You are pregnant or unwilling to use contraception - You are not competent to consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTclinical and neuropsychological testing

Patients are monitored with Brief Psychiatric Rating Scale (BPRS) weekly and structural and functional MRI and MATRICS battery before and at the end of the course of the study

Locations(1)

The Zucker Hillside Hospital

Glen Oaks, New York, United States

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NCT04763655

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