Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

This study compares two treatments — tamoxifen (a hormone-blocking drug) and etoposide (a chemotherapy drug) — for patients with glioblastoma (an aggressive brain tumor) that has come back after first-line treatment. **You may be eligible if...** - You have been diagnosed with glioblastoma confirmed by biopsy - Your tumor has progressed or returned after standard first-line treatment (chemoradiotherapy with temozolomide) - Your disease progression has been confirmed by MRI with at least one measurable tumor visible on imaging - You have not received radiation therapy within the past three months **You may NOT be eligible if...** - Your glioblastoma has not been confirmed by biopsy - You have had radiation therapy within the past 3 months - Your tumor progression is not measurable on MRI Talk to your doctor to see if this trial is right for you.