MRI Hypoxia Study for Glioblastoma Multiforme (GBM) Radiation Therapy

Exclusion Criteria9

• Women lactating, pregnant or of childbearing potential who are not willing to avoid pregnancy during the study
• Patients with a history of severe renal disease(s) (eGFR <20) that cannot tolerate gadolinium chelate contrast agents.
• Geographically remote patients unable to agree to imaging schedule
• Patients who have received anti - vascular endothelial growth factor (anti-VEGF) monoclonal antibody therapy the 3 months prior to recruitment
• Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.
• Patients with significant cardiac or pulmonary disease including cardiac arrythmias or Chronic Obstructive Pulmonary Disease (COPD) that are unable to tolerate high flow O2 for oxygen contrast.
• Patients taking carbonic anhydrase inhibitors (Acetazolamide)
• History of glaucoma
• Any implant, foreign body, 3 Tesla (3T) MRI incompatible device, or other contraindication to MRI imaging.