Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV)

This study, GENE-MAV, is investigating the genetic causes of brain and spinal arteriovenous malformations (AVMs) — abnormal tangles of blood vessels in the brain or spinal cord that can rupture and cause stroke or hemorrhage. While it is known that some AVMs run in families and have genetic causes, many cases are sporadic and the underlying genes are not fully understood. Identifying these genetic factors could improve risk prediction, screening of family members, and eventually lead to new treatment targets. Participants are people with a confirmed AVM who are already being monitored or treated at participating medical centers in France. There are no age restrictions — any patient (including children, with guardian consent) with a vascular malformation identified on brain or spine imaging may participate. You may be eligible if... - You have a vascular malformation of the brain or spinal cord confirmed on imaging (CT angiography, MRI angiography, or diagnostic angiography) - You are scheduled for clinical monitoring alone, or for treatment (endovascular, surgical, or radiosurgery) - You are treated at a participating center You may NOT be eligible if... - You are pregnant, recently gave birth (parturient), or are breastfeeding Talk to your doctor to see if this trial is right for you.