Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
400 participants
Jan 1, 2021
OBSERVATIONAL
Conditions
Summary
In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality. Nowadays, PS is commonly used in newborn infants with respiratory distress, but the incidences of bronchopulmonary dysplasia(BPD) and/or death are inconsistent. The result indicates that not all preterm infants with respiratory distress can be beneficial from PS. In 2017, the international neonatal ARDS (NARDS) collaborative group provides the first consensus definition for NARDS. And whether or not PS being beneficial for preterm infants with NARDS remains unknown.
Eligibility
Inclusion Criteria4
- Eligibility requirements for neonates were as follows:
- The gestational age is less than 37 weeks and admitted to neonatal intensive care unit(NICU) in 24 h after birth
- The neonates will be diagnosed with NRDS or NARDS
- The neonates will be at least administrated one dose of surfactant
Exclusion Criteria4
- one of the following criteria will be needed
- major congenital anomalies
- chromosomal abnormalities
- upper respiratory tract abnormalities
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Interventions
the preterm infants diagnosed with NRDS and/or NARDS will be administrated with only one dose of surfactant
the preterm infants diagnosed with NRDS and/or NARDS will be administrated with two and more doses of surfactant
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04777760