Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

This trial is testing whether combining tiny cancer-fighting nanoparticles with highly precise radiation therapy (called MRI-guided SBRT) can improve treatment for people with lung tumors or pancreatic cancer located near critical structures. The nanoparticles are designed to make cancer cells more sensitive to radiation. **You may be eligible if...** - You have confirmed non-small cell lung cancer (NSCLC) or a lung/lymph node metastasis from another cancer located in or near the central airways, OR - You have confirmed pancreatic cancer - Your tumor is located in a specific region near the central airway or pancreas - Your cancer has been confirmed by imaging, biopsy, or lab testing **You may NOT be eligible if...** - Your tumor is not in the specific areas required for this treatment approach - You have other health conditions that make this combination treatment unsafe Talk to your doctor to see if this trial is right for you.