An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response

This study is testing a specialized MRI technique called intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) to see if it can track how well chemotherapy is working against colorectal cancer that has spread to the liver (called colorectal liver metastases, or CLM). This is an imaging-only study aimed at improving treatment monitoring without additional invasive tests. **You may be eligible if...** - You have colorectal cancer that has spread to your liver (liver metastases) - Your liver metastases are resectable (can potentially be removed by surgery) - You are starting chemotherapy before surgery at MD Anderson Cancer Center - You have at least one liver metastasis measuring 1 cm or larger - You will have follow-up appointments at MD Anderson before and after surgery **You may NOT be eligible if...** - Your liver metastases cannot be surgically removed - You have conditions that prevent MRI scanning - You are not being treated at MD Anderson Talk to your doctor to see if this trial is right for you.