RecruitingNCT04804618

Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease

Exploring Research on Early Warning Indicators of Protein in Patients With Mild Cognitive Impairment and Alzheimer's Disease

Sponsor

Guangzhou University of Traditional Chinese Medicine

Enrollment

650 participants

Start Date

Jun 1, 2021

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease, Early Onset Protein; Disease

Summary

This study intends to adopt standardized and rigorous cross-sectional research, collect biological specimens (including blood, feces, urine, saliva and tongue coating) from eligible subjects, and use liquid chromatography/mass spectrometry (LC-MS/MS) technology to explore early warning indicators of protein in patients with mild cognitive impairment and Alzheimer's disease

Eligibility

Min Age: 55 Years

Inclusion Criteria4

Older than 55-year-old，male or female.
patients meet the diagnosis of mild cognitive impairment (MCI) or Alzheimer's disease(AD) or whose family members were diagnoed with AD
Complete self-rating scale for memory impairment (AD-8 scale)
Those who agree to participate in clinical research and sign informed consent.

Exclusion Criteria2

Patients with acute cardiovascular and cerebrovascular diseases, acute infections (pneumonia, urinary tract infection, oral infection, digestive tract infection), severe renal dysfunction, and uremia;
Pregnant or lactating women;