Neoadjuvant Treatment Modalities in Esophageal Cancer

This trial studies which pre-surgery treatment approach (chemotherapy, radiation, immunotherapy, or combinations) works best for people with esophageal or esophago-gastric junction cancer. You may be eligible if... - You are 18 or older - You have biopsy-confirmed esophageal or esophago-gastric cancer (squamous cell or adenocarcinoma), staged I–IVa - Your treatment is being done at the Cancer Hospital, Chinese Academy of Medical Sciences - Your performance status (ECOG) is 0 or 1 - Your expected survival is at least 3 months - Your blood counts and organ function (blood, liver, kidneys) are within acceptable ranges You may NOT be eligible if... - Cancer has spread to distant organs (liver, lung, bone, brain, etc.) - You have had another cancer in the past 5 years (except certain skin or cervical cancers) - You have an active infection (e.g., active TB or hepatitis) - You had a heart attack within the past 6 months, or have serious heart rhythm problems - You have uncontrolled medical conditions like active infections or unstable heart disease Talk to your doctor to see if this trial is right for you.