RecruitingNot ApplicableNCT04822649

Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

Differences in Cardiopulmonary Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition in Patients With Suspected Heart Failure With Preserved Ejection Fraction


Sponsor

Korea University Anam Hospital

Enrollment

100 participants

Start Date

Apr 15, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.


Eligibility

Min Age: 20 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how small blood vessel problems in the heart (called coronary microvascular dysfunction) affect a person's ability to exercise, and whether body composition (like the amount of muscle versus fat) plays a role. Participants undergo exercise testing and heart imaging to better understand these connections. **You may be eligible if...** - You are between 20 and 80 years old - You experience chest pain, atypical chest discomfort, or shortness of breath - Your coronary angiogram or CT scan did not show significant blockages - Your heart's pumping function is normal (50% or above) **You may NOT be eligible if...** - You have significant heart valve disease or a congenital heart defect - You have severe kidney disease or are on dialysis - You have asthma, COPD, or pulmonary hypertension - You have atrial fibrillation - You are unable to perform exercise testing (treadmill or bicycle) - You are currently taking cancer treatments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTAdenosine stress echocardiography with the evaluation of coronary artery blood flow

The color Doppler flow of distal left anterior descending artery will be examined from the modified apical four-chamber view in the anterior interventricular groove. In regard to body composition analysis, Using InBody S10, impedance is measured in 6 frequency bands (1 kilohertz (kHz), 5 kHz, 50 kHz, 250 kHz, 500 kHz, 1000 kHz) for each of 5 parts (right plate, left arm, torso, right leg, left leg). Reactance is measured in 3 frequency bands (5 kHz, 50 kHz, 250 kHz for each of 5 parts (right arm, left arm, torso, right leg, left leg). By treadmill exercise test with modified Bruce protocol or bicycle ergometer for patients with orthopedic problems, maximal oxygen consumption (VO2 max) will be measured using the exhalation gas analysis.


Locations(1)

Korea University Anam Hospital

Seoul, South Korea

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NCT04822649


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