RecruitingNot ApplicableNCT04822649

Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

Differences in Cardiopulmonary Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition in Patients With Suspected Heart Failure With Preserved Ejection Fraction

Sponsor

Korea University Anam Hospital

Enrollment

100 participants

Start Date

Apr 15, 2021

Study Type

INTERVENTIONAL

Conditions

Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.

Eligibility

Min Age: 20 YearsMax Age: 80 Years

Inclusion Criteria4

Age 20 to 80
Typical/atypical chest pain or ischemic symptoms including dyspnea
No significant coronary artery stenosis (\>50% stenosis) in coronary angiography or computed tomography
Left ventricular ejection fraction ≥50%

Exclusion Criteria9

More than moderate valvular heart disease
Congenital heart disease
Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
Receiving anticancer drugs
Vasculitis associated with autoimmune diseases
Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
Atrial fibrillation
Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients

Interventions

DIAGNOSTIC_TESTAdenosine stress echocardiography with the evaluation of coronary artery blood flow

The color Doppler flow of distal left anterior descending artery will be examined from the modified apical four-chamber view in the anterior interventricular groove. In regard to body composition analysis, Using InBody S10, impedance is measured in 6 frequency bands (1 kilohertz (kHz), 5 kHz, 50 kHz, 250 kHz, 500 kHz, 1000 kHz) for each of 5 parts (right plate, left arm, torso, right leg, left leg). Reactance is measured in 3 frequency bands (5 kHz, 50 kHz, 250 kHz for each of 5 parts (right arm, left arm, torso, right leg, left leg). By treadmill exercise test with modified Bruce protocol or bicycle ergometer for patients with orthopedic problems, maximal oxygen consumption (VO2 max) will be measured using the exhalation gas analysis.