RecruitingNCT06768437

The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction

Sponsor

University of Leicester

Enrollment

130 participants

Start Date

Feb 12, 2025

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the role of epicardial fat (fat tissue surrounding the heart) in heart failure with preserved ejection fraction (HFpEF) — a type of heart failure where the heart pumps normally but is stiff and doesn't fill well. Researchers want to understand whether this fat contributes to disease severity. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with HFpEF confirmed by a cardiologist using standard diagnostic criteria - You had an echocardiogram (heart ultrasound) within the past 12 months - You can read and understand written English **You may NOT be eligible if...** - Your heart pumping function is severely reduced (ejection fraction below 45%) - You have severe valve disease, genetic cardiomyopathy, or other specific structural heart conditions - You have been diagnosed with certain rare causes of heart failure such as cardiac amyloidosis, sarcoidosis, or congenital heart disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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