RecruitingNCT06768437

The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction

Sponsor

University of Leicester

Enrollment

130 participants

Start Date

Feb 12, 2025

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Participant is willing and able to give informed consent for participation in the study.
Aged ≥18 years old
Diagnosed with HFpEF and diagnosis confirmed by an experienced cardiologist using the HFA-PEFF diagnostic algorithm
Echocardiogram performed within 12 months
Able to understand written English

Exclusion Criteria6

LV ejection fraction \<45%
Severe primary valvular heart disease
HFpEF due to infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy/pericardial disease or congenital heart disease
Known heritable, idiopathic or drug-induced pulmonary arterial hypertension
Absolute contraindications to cardiac CT or MRI including estimated glomerular filtration rate (eGFR) ≤30ml/min/1.73m2. Patients with MRI-compatible devices are be excluded.
Women who are pregnant