Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
A Prospective Observational Cohort Study of Predictive Factors Related to Prognosis of In-hosiptal Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
Tongji Hospital
1,000 participants
Mar 1, 2021
OBSERVATIONAL
Conditions
Summary
This is a single-center prospective cohort study of predictive factors related to prognosis of ischemic stroke due to large-artery atherosclerosis. From March 1, 2021 to December 31, 2026, 1000 patients with ischemic stroke due to large-artery atherosclerosis who are admitted to the Department of Neurology or Neurosurgery, Tongji Hospital are going to be recruited. Detailed clinical data in emergency room and in-hospital will be obtained from the medical record reviews, and the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) score will be done by certified neurologists to assess the severity of the disease in acute stage and treatment outcome during the follow-up. All cases will undergo routine blood tests, brain magnetic resonance imaging (MRI) and cerebral vascular examination, such as TCD, CTA, HRMR or DSA. The investigators will analyze the in-hospital factors that could predict the outcome to provide more evidence-based suggestions in the treatment and prognosis of atherosclerotic ischemic cerebrovascular disease.
Eligibility
Inclusion Criteria4
- Ischemic stroke due to large-artery atherosclerosis has been proved by clinical symptoms and imaging examinations.
- Symptomatic superior arch stenosis >50%
- Asymptomatic superior arch stenosis was >70%
- written informed consent was obtained from patients or their surrogates before enrollment.
Exclusion Criteria3
- Brain CT or MRI showing cerebral hemorrhage (excluded ischemic stroke with hemorrhage transformation)
- With severe systemic disease, are expected to survive < 3 months
- Patients will not able to provide continuous follow-up information
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Interventions
common treatments for carotid artery stenosis
common treatments for carotid artery stenosis
the dosage and duration
the dosage and duration
the dosage and duration
the dosage and duration
the dosage and duration
Locations(1)
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NCT04847752