RecruitingNot ApplicableNCT04865471

Resection And Partial Liver Segmental Transplantation With Delayed Total Hepatectomy

Resection And Partial Liver Segmental Transplantation With Delayed Total Hepatectomy as Treatment for Selected Patients With Unresectable Liver Metastases From Colorectal Carcinoma

Sponsor

Azienda Ospedaliera di Padova

Enrollment

18 participants

Start Date

Oct 1, 2020

Study Type

INTERVENTIONAL

Conditions

Liver Metastases

Summary

RAPID is an auxiliary liver transplantation where a small liver partial graft (namely left lateral segments from living or cadaveric donors) is implanted orthotopically after a left hepatectomy of the native liver. Subsequently, in order to implement a fast regeneration of the transplanted segments a portal flow diversion is operated in the direction of the future remnant. After obtaining a fast regeneration of the auxiliary future remnant liver the native liver hepatectomy is completed as in a two stage- hepatectomy. Peculiar inclusion criteria will be adopted for patient selection with particular reference to the admission of patients with \<3 lung metastases radically treated before transplantation.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a novel surgical approach called RAPID (Resection And Partial liver segmental transplantation with Delayed total hepatectomy) for people with colorectal cancer that has spread extensively to the liver and cannot be removed by standard surgery. **You may be eligible if...** - You are between 18 and 70 years old and in good health (ECOG 0–1) - You have colorectal cancer that originated in the colon or rectum, confirmed by biopsy - Your liver metastases have been assessed as not removable by standard liver surgery - You have already completed at least 3 months of chemotherapy - At least 6 months have passed since your colon/rectal surgery **You may NOT be eligible if...** - Your primary tumor carries a BRAF mutation - Your liver disease is too extensive for the transplant approach - You have not had adequate prior chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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