An Imaging Technology, Contrast-Enhanced Mammography, in Predicting Breast Cancer

This study evaluates whether contrast-enhanced mammography (CEM) — a type of mammogram that uses an injected dye to highlight suspicious areas — can better predict whether a breast abnormality is cancerous before a biopsy is done. The goal is to improve how doctors assess suspicious findings and reduce unnecessary biopsies. **You may be eligible if...** - You are a woman between 25 and 85 years old - You have a suspicious breast finding that has been recommended for a stereotactic (image-guided) biopsy - You plan to have your biopsy at MD Anderson Cancer Center - You are willing to receive an IV contrast injection and provide informed consent **You may NOT be eligible if...** - You have had an allergic reaction to iodinated (X-ray) contrast dye before - You have a history of severe allergic reactions (anaphylaxis) to any substance - You have kidney problems - You are pregnant or breastfeeding (within 6 months) - You have had breast surgery or a biopsy at the same site within the past 2–6 months Talk to your doctor to see if this trial is right for you.