Neural Correlates of Real World Spatial Navigation in Humans
Duke University
70 participants
Sep 30, 2020
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Eligibility
Inclusion Criteria3
- years of age or older and has undergone RNS system placement
- Willing to provide informed consent and participate the study
- Ability to read and write English fluently
Exclusion Criteria1
- Unwilling to provide informed consent
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Interventions
Deep brain stimulation will be used
Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity.
Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used.
Participants complete questionnaires and assessments to assess subjective emotional experience.
Locations(2)
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NCT04874220