RecruitingNot ApplicableNCT05452122

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Sponsor

University of California, Los Angeles

Enrollment

150 participants

Start Date

Jul 13, 2022

Study Type

INTERVENTIONAL

Conditions

Memory, Delayed

Summary

The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

All epilepsy patients between the ages of 18 and 65 who undergo depth electrode placement for clinical purposes
Eligibility is determined by the epilepsy surgery team (based on neuropsychological testing and on psychiatric evaluation)
Willing to provide informed consent and participate the study

Exclusion Criteria3

Neurological or psychiatric issues, other than epilepsy, that would put the patient at risk
Patient is younger than 18 or older than 65 years of age
Unwilling to provide informed consent

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