RecruitingPhase 2NCT04888481

68Ga-HA-DOTATATE Imaging of Suspected Somatostatin Receptor Positive Tumors


Sponsor

University of Alberta

Enrollment

600 participants

Start Date

Feb 15, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Somatostatin receptor (SSR) imaging is a critical component of clinical care for many patients being investigated for or with confirmed SSR positive tumors. In the past, 111In-octreotide imaging has been used for this purpose but it has been recently supplanted globally by SSR positron emission tomography (PET) imaging due to better image quality and higher diagnostic accuracy. This study will assess the safety and diagnostic effectiveness of 68Ga-HA-DOTATATE produced a the Edmonton Radiopharmaceutical Centre (ERC).


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new type of imaging scan using a radioactive tracer called 68Ga-HA-DOTATATE to detect and map tumors that have a special protein on their surface (somatostatin receptors). These include neuroendocrine tumors, pheochromocytomas, paragangliomas, and certain brain tumors. **You may be eligible if...** - You have a known or suspected somatostatin receptor-positive tumor (such as neuroendocrine tumors of the gut, pancreas, lungs, pheochromocytoma, paraganglioma, medullary thyroid cancer, meningioma, or medulloblastoma) - You have had a standard CT or MRI scan within the past 6 months - You are able to give written consent **You may NOT be eligible if...** - You weigh more than 225 kg (the weight limit of the scanner) - You cannot lie still or have severe claustrophobia - You have had an allergic reaction to DOTATATE or similar medications (somatostatin analogues) - You do not have IV (intravenous) access - You have a serious medical condition that would interfere with the scan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG68Ga-HA-DOTATATE

Tracer injection


Locations(1)

University of Alberta

Edmonton, Alberta, Canada

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NCT04888481


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