RecruitingPhase 4NCT04899479

Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention

Peri-tREatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index Measured by Cardiac maGnetic rEsonance Imaging in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention


Sponsor

Samsung Medical Center

Enrollment

200 participants

Start Date

Jul 5, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and high risk of heart failure, and its mechanism. For this reason, we compared cardiac magnetic resonance imaging (CMR) parameters and clinical outcomes between the SGLT-2 inhibitor group and the control group to confirm the efficacy and safety of SGLT-2 inhibitors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether giving an SGLT-2 inhibitor (a type of diabetes and heart medication) around the time of a heart procedure can reduce heart muscle damage and prevent the heart from enlarging after a heart attack. Participants receive a stent procedure to open blocked arteries. **You may be eligible if...** - You are 18 or older and have been diagnosed with a heart attack (STEMI or NSTEMI) - Your heart pumping function is less than 50%, or you have signs of fluid buildup in the lungs - You are scheduled for a procedure to open a blocked artery (PCI/stent) **You may NOT be eligible if...** - The blocked artery is not suitable for a stent - You needed emergency heart resuscitation before the procedure - You have had a previous heart attack or previous heart failure - You are already taking an SGLT-2 inhibitor (such as empagliflozin, dapagliflozin, or canagliflozin) - You have type 1 diabetes or active infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGSGLT2 inhibitor

In patients with AMI and high risk of heart failure, 1:1 randomization will be performed to either SGLT2 inhibitor or control group.

OTHERControl

In patients with AMI and high risk of heart failure, 1:1 randomization will be performed to either SGLT2 inhibitor or control group.


Locations(1)

Samsung Medical Center

Seoul, South Korea

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04899479


Related Trials