RecruitingNCT04899635

POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

Profiling Biomechanical Responses and Workload of the Human Myocardium to Explore the Concept of Myocardial Fatigue and Reversibility

Sponsor

University Hospitals Coventry and Warwickshire NHS Trust

Enrollment

100 participants

Start Date

Aug 3, 2021

Study Type

OBSERVATIONAL

Conditions

Heart Failure Fatigue; Muscle, Heart Myocardial Dysfunction Exhaustion; Heart

Summary

To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study examines how heart muscle gets tired (fatigues) during pumping by analyzing small samples of heart tissue. The goal is to better understand how the heart works at a microscopic level, which could help improve future treatments for heart disease. **You may be eligible if...** - You are 18 to 85 years old - You are scheduled for open-heart surgery - You are able to understand and agree to participate - Donor hearts not used for transplant may also be included with consent from a legal representative **You may NOT be eligible if...** - You do not have the mental capacity to provide consent - You have an active blood-borne infection such as HIV - You have had a recent positive COVID-19 test within the past 10 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERIn-vitro contractile fatigue protocol

Using contractility assays for muscle slices or the work-loop assay for isolated heart cells, the tissue preparation will undergo a series of contraction and relaxation under varying levels of preload, afterload, stimulation frequency and under other experimental conditions such as drug-induced inotropism.

Locations(1)

University Hospitals Coventry and Warwickshire

Coventry, United Kingdom

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NCT04899635

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