RecruitingNCT04908696

Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)

Department of Otorhinolaryngology, Eye & ENT Hospital

Sponsor

Eye & ENT Hospital of Fudan University

Enrollment

1,000 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Glottic Carcinoma Supraglottic Carcinoma Subglottic Carcinoma Pyriform Sinus Carcinoma Postcricoid Carcinoma Posterior Pharyngeal Wall Carcinoma

Summary

For early stage laryngeal carcinoma and hypohparyngeal carcinoma (T1 and T2), transoral laser microsurgery, open partial laryngectomy, radiotherapy, and transoral robotic surgery were performed according to NCCN guidelines (2020). For advanced stage laryngeal carcinoma and hypohparyngeal carcinoma (T3 and T4), surgical treatment ± postoperative adjuvant therapy, chemoradiotherapy, neoadjuvant therapy + radiotherapy/chemoradiotherapy, or neoadjuvant therapy + surgery + radiotherapy or chemoradiotherapy performed according to NCCN guidelines (2020). This study plan to analyze the clinical ouctomes of different treatment for the same T stage disease. The overall survival rate, disease specific survival, disease free survival, local control, regional control, and laryngeal function preservation rate were analyzed in this study.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study examines treatments for laryngeal (voice box) and hypopharyngeal (lower throat) cancers across different stages and locations, aiming to compare outcomes and identify best practices for these specialized head and neck cancers. **You may be eligible if...** - You have been diagnosed with laryngeal cancer (glottic, supraglottic, or subglottic) or hypopharyngeal cancer - Your cancer is at any stage (T1 through T4) - You are between 18 and 90 years old - You do not have other serious illnesses that would affect treatment - Women with childbearing potential must have a negative pregnancy test **You may NOT be eligible if...** - You have a known immune deficiency or HIV/AIDS - You have active tuberculosis - You are pregnant or breastfeeding - Your doctor determines participation is not appropriate based on your overall health Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREroutines

For early stage laryngeal carcinoma and hypohparyngeal carcinoma (T1 and T2), transoral laser microsurgery (CO2 laser resection), open partial laryngectomy (vertical partial laryngectomy, cricohyoidoepiglottopexy, cricohyoidopexy, horizontal partial laryngectomy), partial hypopharyngectomy, radiotherapy, and transoral robotic surgery were performed for patients with proper indications (NCCN 2020). For advanced stage laryngeal carcinoma and hypohparyngeal carcinoma (T3 and T4), surgical treatment ± postoperative adjuvant therapy, concurrent chemoradiotherapy, neoadjuvant therapy + radiotherapy/chemoradiotherapy, or neoadjuvant therapy + surgery + radiotherapy or chemoradiotherapy were performed for patients with proper indications (NCCN 2020).

Locations(1)

Lei Tao

Shanghai, Shanghai Municipality, China

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