RecruitingPhase 4NCT04916197

Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)

Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With Endovascular Thrombectomy on Long-term Prognosis in Patients With Acute Ischemic Stroke (PPDET)

Sponsor

Beijing Chao Yang Hospital

Enrollment

368 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Acute Ischemic Stroke

Summary

Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after successful reperfusion of endovascular thrombectomy may improve the clinical outcome of acute ischemic stroke patients.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 0.9% saline and a drug called Dexmedetomidine prolonged sedation for people with acute ischemic stroke. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexmedetomidine prolonged sedation

Dexmedetomidine for 24h after patients finished endovascular thrombectomy and returned to ICU.

DRUG0.9% saline

An equal dose of 0.9% saline 24h after patients finished endovascular thrombectomy and returned to ICU.

Locations(1)

Beijing ChaoYang Hospital

Beijing, Beijing Municipality, China

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NCT04916197

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