RecruitingNot ApplicableNCT04916327

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1


Sponsor

Virginia Commonwealth University

Enrollment

720 participants

Start Date

Aug 23, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).


Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study (Study 1) is examining how PTSD (post-traumatic stress disorder) and generalized anxiety disorder (GAD) affect blood vessel health, and whether exercise training can improve those effects. **You may be eligible if:** - You are generally healthy without known heart, lung, or metabolic disease - You have PTSD symptoms (scoring 33 or higher on the PCL-5 checklist), OR - You have generalized anxiety (scoring 10 or higher on the GAD-7 scale without high PTSD symptoms), OR - You are a healthy volunteer with low anxiety and no PTSD **You may NOT be eligible if:** - You take medications that affect heart or blood vessel function - You are a recent or current smoker - You use illicit drugs or drink excessive amounts of alcohol - You are pregnant - You have significant nutritional deficiencies - You have limited English proficiency Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTAntioxidant

Subjects will ingest an antioxidant cocktail containing 800 milligrams of alpha lipoic acid, 1 gram of vitamin C (ascorbic acid), and 400 milligrams of vitamin E (alpha tocopherol).

DIETARY_SUPPLEMENTPlacebo

Subjects will ingest placebo (microcrystalline cellulose) pills.


Locations(1)

Virginia Commonwealth University

Richmond, Virginia, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04916327


Related Trials