RecruitingNot ApplicableNCT04916340

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3

Sponsor

Virginia Commonwealth University

Enrollment

240 participants

Start Date

Jan 24, 2022

Study Type

INTERVENTIONAL

Conditions

Peripheral Vascular Diseases

Summary

The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study (Study 3) is examining how PTSD and generalized anxiety disorder affect blood vessel health, and whether exercise training can improve vascular function in people with these mental health conditions. **You may be eligible if:** - You are generally healthy without known heart, lung, or metabolic disease - You have PTSD symptoms (scoring 33 or higher on the PCL-5 checklist), OR - You have generalized anxiety (scoring 10 or higher on the GAD-7 scale without high PTSD symptoms), OR - You are a healthy volunteer with low anxiety and no PTSD **You may NOT be eligible if:** - You take medications that affect heart or blood vessel function - You are a recent or current smoker - You use illicit drugs or drink excessive amounts of alcohol - You are pregnant - You have significant nutritional deficiencies - You have limited English proficiency Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMuscular Strength Training Group

Week 1 3 days/week Bench Press - 1 set at 80% of one repetition maximum (1RM) Bent Over Row - 1 set at 80% 1RM Back Squat - 1 set at 80% 1RM Romanian Deadlift - 1 set at 80% 1RM Week 2 3 days/week Bench Press - 2 sets at 80% 1RM Bent Over Row - 2 sets at 80% 1RM Back Squat - 2 sets at 80% 1RM Romanian Deadlift - 2 sets at 80% 1RM Weeks 3-10 3 days/week Bench Press - 3 sets at 80% 1RM Bent Over Row - 3 sets at 80% 1RM Back Squat - 3 sets at 80% 1RM Romanian Deadlift - 3 sets at 80% 1RM

BEHAVIORALMuscular Fitness Training Group

Week 1 3 days/week Bench Press - 1 set at 65% 1RM Bent Over Row - 1 set at 65% 1RM Back Squat - 1 set at 65% 1RM Romanian Deadlift - 1 set at 65% 1RM Week 2 3 days/week Bench Press - 2 sets at 65% 1RM Bent Over Row - 2 sets at 65% 1RM Back Squat - 2 sets at 65% 1RM Romanian Deadlift - 2 sets at 65% 1RM Weeks 3-10 3 days/week Bench Press - 3 sets at 65% 1RM Bent Over Row - 3 sets at 65% 1RM Back Squat - 3 sets at 65% 1RM Romanian Deadlift - 3 sets at 65% 1RM