RecruitingNot ApplicableNCT04922762

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2

Sponsor

Virginia Commonwealth University

Enrollment

360 participants

Start Date

Dec 6, 2021

Study Type

INTERVENTIONAL

Conditions

Peripheral Vascular Diseases

Summary

The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study (Study 2) is examining how PTSD and generalized anxiety disorder affect blood vessel function, and whether exercise training can reverse these effects. **You may be eligible if:** - You are generally healthy without known heart, lung, or metabolic disease - You have PTSD symptoms (scoring 33 or higher on the PCL-5 checklist), OR - You have generalized anxiety (scoring 10 or higher on the GAD-7 scale without high PTSD symptoms), OR - You are a healthy volunteer with low anxiety and no PTSD **You may NOT be eligible if:** - You take medications that affect heart or blood vessel function - You are a recent or current smoker - You use illicit drugs or drink alcohol excessively - You are pregnant - You have significant nutritional deficiencies - You have limited English proficiency Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALModerate Intensity, Normal Volume Exercise Training

Week 1 3 days/week for 20 minutes/day Performed at 70% of heart rate maximum Week 2 3 days/week for 30 minutes/day Performed at 70% of heart rate maximum Weeks 3-10 3 days/week for 45 minutes/day Performed at 70% of heart rate maximum

BEHAVIORALHigh Intensity, Normal Volume Exercise Training

Week 1 3 days/week for 31 minutes/day 10 minute warm up at 50% of heart rate maximum 2 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 7 minute cool down at 50% of heart rate maximum Week 2 3 days/week for 38 minutes/day 10 minute warm up at 50% of heart rate maximum 3 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 2 TIMES 7minute cool down at 50% of heart rate maximum Weeks 3-10 3 days/week for 45 minutes/day 10 minute warm up at 50% of heart rate maximum 4 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 3 TIMES 7 minute cool down at 50% of heart rate maximum

BEHAVIORALModerate Intensity, High Volume Exercise Training

Week 1 5 days/week for 20 minutes/day Performed at 70% of heart rate maximum Week 2 5 days/week for 30 minutes/day Performed at 70% of heart rate maximum Weeks 3-10 5 days/week for 45 minutes/day Performed at 70% of heart rate maximum