Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs
Diaphragmatic Function, Pain Quality & Anti-inflammatory Properties: A Low Dose Dexmedetomidine Versus Ketamine in Patients With Multiple Fracture Ribs Needing Conservative Treatment
Assiut University
60 participants
Jun 12, 2021
INTERVENTIONAL
Conditions
Summary
In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.
Eligibility
Inclusion Criteria5
- Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II
- Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT
- Undergoing conservative treatment (chest strappings)
- Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies
- Glasgow Coma Scale (GCS) ≥ 13.
Exclusion Criteria10
- Multiple traumas to body parts other than chest with an abbreviated injury scale over 3
- Serious head trauma with a Glasgow coma scale lower than 13
- Mechanically ventilated patients
- Massive hemothorax
- Injury to the trachea or bronchus with requirement for immediate surgery
- Dementia
- Use of corticosteroids during ICU stay
- Sepsis
- Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity
- Contraindication to the study drugs.
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Interventions
low dose dexmedetomidine infusion 0.2 µ/kg/hour IV for 5 days.
the same dose and duration of normal saline will be given for 5 days.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04928300