RecruitingNot ApplicableNCT04933266

Subpectoral Plexus Block With Multi-level TPVB for Surgical Anesthesia During Primary Breast Cancer Surgery

Ultrasound-guided Subpectoral Plexus Block With Multi-level Thoracic Paravertebral Block for Surgical Anaesthesia During Primary Breast Cancer Surgery: A Prospective Randomized Double-blind Trial


Sponsor

Chinese University of Hong Kong

Enrollment

100 participants

Start Date

Mar 15, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The objective of this study is to compare two different doses of local anesthetics (10ml vs 20ml of 0.25% levobupivacaine) for subpectoral plexus block (SPPB) in addition to ultrasound guided multi-level of thoracic paravertebral block (m-TPVB) for surgical anaesthesia for major primary breast cancer surgery.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a new nerve-blocking technique (a combination of subpectoral plexus block and thoracic paravertebral blocks) to provide pain relief during and after breast cancer surgery, reducing the need for general anesthesia or opioid pain medications. **You may be eligible if...** - You are scheduled for breast cancer surgery, including mastectomy, modified radical mastectomy, or breast-conserving surgery - Your procedure may include lymph node biopsy or removal from the armpit **You may NOT be eligible if...** - You have a skin infection at the injection site - You have a blood clotting disorder (coagulopathy) - You have a known allergy to local anesthetic medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESubpectoral plexus block (low dose)

It is one type of peripheral nerve blocks for surgery over the chest. Patients will have an ultrasound scan and nerve block with local anesthetic (LA) agent (0.25% levobupivacaine 10ml) injected 2 target sites through one skin puncture. One at the myofascial plane between the pectoralis major and minor (5ml of LA) and then under direct ultrasound visualization, the needle will be redirected and the remaining 5ml of LA will be injected at the plane between the pectoralis minor and the serratus anterior muscle, close to the origin of thoracoacromial artery from the axillary artery at the level of the third rib.

PROCEDURESubpectoral plexus block (High dose)

It is one type of peripheral nerve blocks for surgery over the chest. Patients will have an ultrasound scan and nerve block with local anesthetic (LA) agent (0.25% levobupivacaine 20ml) injected 2 target sites through one skin puncture. One at the myofascial plane between the pectoralis major and minor (10ml of LA) and then under direct ultrasound visualization, the needle will be redirected and the remaining 10ml of LA will be injected at the plane between the pectoralis minor and the serratus anterior muscle, close to the origin of thoracoacromial artery from the axillary artery at the level of the third rib.


Locations(1)

North District Hospital

Sheung Shui, New Territories, Hong Kong

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NCT04933266


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