RecruitingNot ApplicableNCT04933435

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

Phase II Non-Randomized Trial of Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

Sponsor

Duke University

Enrollment

78 participants

Start Date

Nov 12, 2020

Study Type

INTERVENTIONAL

Conditions

Liver Cancer

Summary

This is a research study to evaluate change in Quality of Life, as defined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC C-30), from baseline to 1 month post treatment in two patient cohorts receiving Interventional Radiology Liver Directed Therapies or Hypofractionated Image-Guided Radiation Therapy.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study compares two non-surgical treatments for liver cancer in patients who cannot have surgery: interventional radiology procedures (like tumor ablation or embolization) versus high-precision radiation therapy (hypofractionated image-guided radiotherapy). **You may be eligible if...** - You have been diagnosed with hepatocellular carcinoma (primary liver cancer) - You are 18 or older and in reasonably good physical condition (ECOG 0-2) - You have good enough liver function (Child-Pugh class A or B7/B8) - You have no more than 3 liver tumors, each no larger than 5 cm - Surgery is not an option for your liver cancer **You may NOT be eligible if...** - Your liver function is severely impaired (Child-Pugh B9 or Class C) - You have uncontrolled fluid buildup in the abdomen (ascites) - You are currently receiving systemic (whole-body) therapy for liver cancer - You have had prior radiation to the liver area Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERQuality of life questionnaires

European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (QLQ-C30) and Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep)