Obeticholic Acid for Prevention in Barrett's Esophagus

This study tests whether a drug called obeticholic acid can prevent Barrett's esophagus — a precancerous condition in the esophagus caused by acid reflux — from progressing toward cancer. **You may be eligible if...** - You have been diagnosed with Barrett's esophagus (confirmed by biopsy) with no dysplasia, low-grade dysplasia, or results that are uncertain (indefinite for dysplasia) - Your Barrett's esophagus affects at least 2 cm of the esophagus - You are currently taking proton pump inhibitor (acid-reducing) medication for at least 28 days - You are 18 or older and in reasonably good health **You may NOT be eligible if...** - Your Barrett's esophagus has already progressed to high-grade dysplasia or cancer - You are not taking acid-reducing medication - You are pregnant or breastfeeding - You have significant liver disease Talk to your doctor to see if this trial is right for you.