RecruitingNot ApplicableNCT04954664

Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor

Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical and Histological Randomized Controlled Trial


Sponsor

University of Alabama at Birmingham

Enrollment

44 participants

Start Date

Aug 11, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This study will compare two techniques to achieve increase in ridge dimensions as a preparation for dental implants using a resorbable barrier membrane and bone particulate allogenic graft hydrated with saline or a growth factor called Recombinant Human Platelet-Derived Growth Factor (rhPDGF).


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study compares two techniques for rebuilding a thin or narrow jawbone (alveolar ridge) to prepare it for a dental implant: one uses donor bone particles alone (allograft), and the other uses donor bone particles combined with a special growth factor called rhPDGF-BB that may speed up bone regeneration. This is for patients who don't have enough bone width to place an implant without a bone graft first. You may be eligible if: - You are 18 years or older - You are a patient of the UAB Dental School - You speak English and can understand the consent form - You need dental implants to replace missing teeth in at least one area of the mouth - A bone scan (CBCT) shows you have 5 mm or less of jawbone width at the implant site You may NOT be eligible if: - You smoke more than 10 cigarettes per day - You have a systemic health condition that prevents oral surgery or impairs wound healing - You have significant vertical bone loss at the implant site - You have a history of poor dental hygiene, alcohol abuse, or drug abuse Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAllograft particles hydrated with rhPDGF

Allograft particles should be hydrated with GEM21S for 20 minutes prior to grafting. The graft sites will be covered with a resorbable barrier membrane.

BIOLOGICALAllograft particles hydrated in a conventional way with saline.

Allograft particles should be hydrated with saline for 20 minutes prior to grafting. The graft sites will be covered with a resorbable barrier membrane


Locations(1)

Unversity of Alabama at Birmingham, School of Dentistry

Birmingham, Alabama, United States

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NCT04954664


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