Cefixime Clinical Trial

This clinical trial is testing whether cefixime — an oral antibiotic — is an effective treatment for early syphilis (primary, secondary, or early latent stages). Syphilis is a bacterial sexually transmitted infection, and standard treatment requires injected penicillin. An effective oral antibiotic would be a major practical advance. **You may be eligible if...** - You are 18 or older - You have been diagnosed with primary, secondary, or early latent syphilis with a positive RPR blood test (titer of 1:8 or higher) within the past 3 weeks - If you have HIV, you must be on HIV treatment and either have a suppressed viral load or a CD4 count of 350 or above **You may NOT be eligible if...** - You are pregnant - You have symptoms suggesting syphilis has spread to the nervous system (neurosyphilis) - Your syphilis RPR blood test has been persistently positive at the same level for over 12 months without responding to treatment (serofast) - You have recently taken (within 7 days) antibiotics that can treat syphilis, such as azithromycin, doxycycline, or ceftriaxone - You are allergic to cephalosporins or penicillin - You are unwilling or unable to attend follow-up visits Talk to your doctor to see if this trial is right for you.