RecruitingNCT04989439

Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants

Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants - a Prospective Explorative Observational Study

Sponsor

Medical University of Vienna

Enrollment

10 participants

Start Date

Jul 19, 2021

Study Type

OBSERVATIONAL

Conditions

Lung Injury Ultrasonography Electric Impedance Computed Tomography Infant ALL

Summary

The study focuses on regional lung examination, in particular on the differentiation between collapsed and hyperinflated lung areas. The purpose of the study is to elaborate common and discriminative elements between different lung imaging modalities in infants and to generate hypotheses for the bedside use of EIT and LUS in infants.

Eligibility

Max Age: 12 Months

Plain Language Summary

Simplified for easier understanding

This study is comparing three methods of imaging the lungs in young infants: CT scans, electrical impedance tomography (EIT), and ultrasound. Researchers want to find out if the safer, radiation-free options (EIT and ultrasound) can provide information that's as useful as a CT scan. You may be eligible if: - Your infant is 12 months old or younger - Your infant is already scheduled to receive a CT scan of the chest at the Vienna Medical University Department of Pediatrics You may NOT be eligible if: - Your infant has unstable heart, breathing, or neurological problems - Your infant had chest surgery within the past 15 days - Your infant has skin wounds or burns on the chest where the EIT belt would be placed Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERElectrical impedance tomography and ultrasonography of the lung

Both EIT and LUS are non-invasive methods and do not pose any additional risk for the patient. The LuMon System with pediatric EIT belts (LuMon Belt, Sentec, Landquart, Switzerland) will be used. The belt will be placed on the thorax circumference of the infant and connected to the LuMonConnector (Sentec, Landquart, Switzerland). Small electrical currents (3 mA, 198 kHz) will be repetitively injected in rotation through adjacent electrode pairs, and voltage changes will be measured by all passive electrodes pairs (scan rate 48 Hz). Changes in lung electrical impedance will be continuously recorded for 5 minutes. EIT data will be analyzed off-line using Matlab (Mathworks, Natick, Massachusetts, USA). The regional tidal volume distribution, the homogeneity of tidal ventilation distribution, regional respiratory system compliance, and alveolar overdistension and collapse will be assessed. LUS will be performed by experienced users, with a 10 MHz linear transducer.