Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants
Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants - a Prospective Explorative Observational Study
Medical University of Vienna
10 participants
Jul 19, 2021
OBSERVATIONAL
Conditions
Summary
The study focuses on regional lung examination, in particular on the differentiation between collapsed and hyperinflated lung areas. The purpose of the study is to elaborate common and discriminative elements between different lung imaging modalities in infants and to generate hypotheses for the bedside use of EIT and LUS in infants.
Eligibility
Inclusion Criteria2
- Patients hospitalized at the Department of Pediatrics of the Medical University of Vienna who will get a CT scan of the thorax.
- Patients aged up to 12 months
Exclusion Criteria3
- Unstable cardiovascular, respiratory and/or neurological conditions.
- Sternotomy during the previous 15 days.
- Thoracic skin lesions or wounds (including burns) on the thorax, where the EIT-electrode-belt would be placed.
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Interventions
Both EIT and LUS are non-invasive methods and do not pose any additional risk for the patient. The LuMon System with pediatric EIT belts (LuMon Belt, Sentec, Landquart, Switzerland) will be used. The belt will be placed on the thorax circumference of the infant and connected to the LuMonConnector (Sentec, Landquart, Switzerland). Small electrical currents (3 mA, 198 kHz) will be repetitively injected in rotation through adjacent electrode pairs, and voltage changes will be measured by all passive electrodes pairs (scan rate 48 Hz). Changes in lung electrical impedance will be continuously recorded for 5 minutes. EIT data will be analyzed off-line using Matlab (Mathworks, Natick, Massachusetts, USA). The regional tidal volume distribution, the homogeneity of tidal ventilation distribution, regional respiratory system compliance, and alveolar overdistension and collapse will be assessed. LUS will be performed by experienced users, with a 10 MHz linear transducer.
Locations(1)
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NCT04989439