RecruitingNot ApplicableNCT04999553

Left vs. Right Non-Inferiority Trial

Left Intermittent Theta Burst Stimulation vs. Right Low Frequency Repetitive Transcranial Magnetic Stimulation Effectiveness in Depression and Suicidal Ideation: A Randomized Non-Inferiority Trial

Sponsor

University of British Columbia

Enrollment

480 participants

Start Date

Nov 8, 2021

Study Type

INTERVENTIONAL

Conditions

Depression Major Depressive Disorder Major Depressive Episode

Summary

The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Intermittent Theta Burst Stimulation (iTBS), a medical device called Low Frequency Right (LFR), and others for people with depression, major depressive disorder, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICERepetitive Transcranial Magnetic Stimulation

rTMS will employ the MagPro X100/R30 stimulator equipped with the cool-B70 as we used a cool-B70 in our past non-inferiority trial. The dose will be a 120% rMT in accordance to our latest trial using iTBS. The target area to stimulate will be the right dorsolateral prefrontal cortex (DLPFC) for LFR and the left DLPFC for iTBS as established in prior clinical trials. The localization of both targets will follow the well-established procedures for either R-DLPFC or L-DLPFC using a heuristic method.

DEVICEIntermittent Theta Burst Stimulation (iTBS)

Intermittent Theta Burst Stimulation (iTBS)

DEVICELow Frequency Right (LFR)

Low Frequency Right (LFR)