RecruitingNot ApplicableNCT05000801

Clinical Study of DC-AML Cells in the Treatment of Acute Myeloid Leukemia

Safety and Feasibility Study of Dendritic Cell (DC) Vaccination Expressing WT1/hTERT/Survivin in AML Patients With Minimal Residual Disease (MRD)


Sponsor

Affiliated Hospital to Academy of Military Medical Sciences

Enrollment

20 participants

Start Date

Jul 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The primary aim of this innovative immunotherapy using WT1/hTERT/Survivin-loaded DCs is to determine whether this novel DC vaccination is safe and can significantly prevent clinical relapse and increase survival of acute myeloid leukemia (AML) patients by eradicating minimal residual disease, while maintaining its safety profile in this phase I trial.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests a special type of immune cell therapy (called DC-AML cells — dendritic cell vaccines made from your own cells) for people with a blood cancer called Acute Myeloid Leukemia (AML) who are in remission but still have small signs of cancer remaining (called measurable residual disease or MRD). **You may be eligible if...** - You have been diagnosed with AML and have completed chemotherapy and achieved remission - You still have trace amounts of cancer detectable in your bone marrow (MRD positive) - You are not eligible for a stem cell transplant, OR you have had a relapse at the molecular level after transplant **You may NOT be eligible if...** - You do not have AML or have not completed standard induction and consolidation chemotherapy - You do not have detectable residual disease - You have significant other health conditions that would make this treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALDC vaccine

Autologous/or HLA-matched donors' DCs loaded with WT1/TERT/survivin


Locations(1)

Department of hematology

Beijing, Beijing Municipality, China

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NCT05000801


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