Opioid/Benzodiazepine Polydrug Abuse: Aim 3

This study is examining how the combination of opioids and sedative drugs (like benzodiazepines or alcohol) affects the brain and behavior. Researchers are recruiting adults who have experience using both types of substances — even recreationally — to better understand the risks of combining these drugs. You may be eligible if: - You are between 18 and 65 years old - You have personal experience over the past 10 years using both opioids and sedatives (or opioids and alcohol, with alcohol used on at least 3 days in the past month) - You are in generally good health - You are not currently seeking treatment for substance use You may NOT be eligible if: - You have a severe psychiatric disorder (psychosis, bipolar disorder, or severe depression) - You have a severe substance use disorder for any substance - You have had a drug overdose or suicidal thoughts in the past year - You currently take methadone, buprenorphine, or naltrexone - You are pregnant, breastfeeding, or sexually active without medically approved birth control (if female) - You have significant neurological, cardiovascular, or pulmonary disease - Your BMI is above 38 Talk to your doctor to see if this trial is right for you.